Serum Estradiol (E2)

Serum Estradiol (E2)

Serum Estradiol (E2) is a crucial hormone in the estrogen family, primarily produced by the ovaries in females and in smaller amounts by the testes in males. It plays a vital role in reproductive health, bone density, and cardiovascular function. Estradiol levels fluctuate throughout the menstrual cycle and can be influenced by various health conditions, medications, and lifestyle factors.

This test is commonly used to assess ovarian function, diagnose hormonal disorders, and monitor conditions such as polycystic ovary syndrome (PCOS), menopause, and infertility. In men, it helps evaluate conditions like gynecomastia and testosterone imbalance. Healthcare providers may order this test if symptoms such as irregular periods, hot flashes, mood swings, or unexplained infertility are present.

During pregnancy, estradiol levels rise significantly, making this test useful in monitoring fetal development. In assisted reproductive treatments like in-vitro fertilization (IVF), estradiol measurement is critical to ensuring a proper response to ovarian stimulation. The test is also used to assess the effectiveness of hormone replacement therapy (HRT) in postmenopausal women.